Serum IL-6 concentrations in the melanoma group seem to be slightly increased compared to the nevi group (9.85 ± 9.32 vs. 5.68 ± 4.81pg/mL, p=0.07, OR = 1.10, 95% CI 1.00–1.23 after multivariate adjustments) and although this cytokine is present in higher concentrations inside LEVs, as int-IL-6, we observed no difference between benign and malignant lesions (14.19 ± 4.12 vs. 14.37 ± 1.41, p=0.7) (Figure 4B). Here, IL6 is linked to melanoma.