Non-small cell lung cancer (NSCLC) cells release circUSP7 via exosome secretion, which upregulates SHP2 expression by sponging miR-934, thereby inhibiting CD8+ T cell secretion of IFN-γ, TNF-α, granzyme B, and perforin and ultimately suppressing CD8+ T cell function (128). This evidence concerns the gene PRF1 and non-small cell lung carcinoma.