TNFRSF14 and cancer: Herpes virus entry mediator (HVEM, also TNFRSF14), a member of the TNF receptor superfamily expressed by both immune and non-immune cells that is frequently upregulated in malignancies, engages B and T lymphocyte attenuator (BTLA) on T cells to trigger co-inhibitory signaling, thereby suppressing TCR-mediated activation and impairing cytotoxic effector function (49, 50).