Moreover, deficiencies in glucose-6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PK) in Plasmodium have been shown to protect against the severe effects of malaria, underscoring the enzymes’ critical role in the parasite’s lifecycle, thereby making PfGluPho a promising target for antimalarial drugs (213). This evidence concerns the gene G6PD and malaria.