Notably, survival analysis identified CHST4 (log-rank P = 0.040), SOX9 (log-rank P = 0.018), and VCAN (log-rank P = 0.037) as prognostic biomarkers significantly correlated with overall survival in HCC patients (Figure 8B), implicating these genes as potential oncogenic drivers during fibrotic malignant transformation. This evidence concerns the gene VCAN and hepatocellular carcinoma.