demonstrated that MYC activates Notch signaling to drive a subtype shift in SCLC subtypes from ASCL1 through NEUROD1 to YAP1 states, facilitating dedifferentiation from neuroendocrine (NE) to non-neuroendocrine (non-NE) phenotypes (41). The gene discussed is YAP1; the disease is small cell lung carcinoma.