SOAT1 and myeloproliferative disorder: In addition, ROS initiate inflammatory pathways and protumorigenic pathways such as p38-mitogen-activated protein kinase, protein kinase B/mammalian target of rapamycin, and JAK/STAT, leading to aberrant cell proliferation, metastasis, resistance to apoptosis, angiogenesis, and other processes crucial for MPN onset and progression [134].