Different machine learning approaches have been used in similar biological classification tasks (Greener et al. 2022), and to provide new insights about CTCF loop formation in AD we developed a new classifier based on XGBoost (Chen and Guestrin 2016), tested it on different cell lines, and compared it against state-of-the-art CTCF loop predictors (Kai et al. 2018, Xu et al. 2023). The gene discussed is CTCF; the disease is Alzheimer disease.