CTCF and Alzheimer disease: Another factor is the idea that changes in control patients and AD samples are related with the cell composition and cell death inherent with AD (Johnson et al. 2020), however, since the CTCF loop landscape is mostly invariant, it is possible to suggest that the changes in CTCF loops, especially those with a high CTCF binding score, account directly for AD-related abnormalities and are shared across the analyzed tissue cell types.