CTCF and early-onset autosomal dominant Alzheimer disease: There is evidence that epigenetic disruptions are able to affect CTCF binding and looping (Monteagudo-Sánchez et al. 2024), and thus, diseases which present epigenetic alterations as a feature may also feature abnormal CTCF binding and CTCF loop disruption, with Alzheimer’s disease (AD) being an example of possible CTCF disruption (Burton et al. 2002).