POLE4 and Alzheimer disease: While it may not be possible to extend the results to the whole spectrum of AD etiology due to an inherent lack of robustness, we can also acknowledge the fact that the genes involved in the loops predicted as lost have also been experimentally described as relevant in AD, such as SHANK2 (Patel et al. 2023) and POLE4 (Ferrer et al. 2021, Patel et al. 2023).