CTCF and Alzheimer disease: Another issue to consider is the fact that changes in CTCF binding and looping may not affect gene expression directly, however, loss of CTCF binding may prevent the formation of CTCF loops in response to cellular events, affecting the ability of the cell to maintain homeostasis (Kaushal et al. 2021, Xu et al. 2021), this suggesting that changes to CTCF in AD may be a cumulative trait during the development of this disease.