There is also evidence of interactions between APOE and CTCF and it is possible for CTCF to make protein complexes directly with AB peptides or Tau hindering its ability to bind DNA (Del Moral-Morales et al. 2023), however, more studies on the topic are required to confirm the existence of either a pattern or a mechanism confirming the role of CTCF and CTCF looping in AD. This evidence concerns the gene APOE and Alzheimer disease.