NLRP3 and Hyperglycemia: Critically, in diabetic pathologies (Zhao et al., 2021), the BSP accelerates refractory wound repair by suppressing hyperglycemia-induced NLRP3 inflammasome activation (TXNIP/NLRP3/caspase-1 pathway), reducing macrophage-derived IL-1β secretion, and improving endothelial insulin sensitivity.