Interestingly, an unbiased chemical–genetic screen in a zebrafish abcd1 mutant (X-linked adrenoleukodystrophy model) identified scd induction as a protective modifier, and pharmacological activation of Scd rescued abnormal motor behavior in that model (Raas et al., 2021). The gene discussed is ABCD1; the disease is X-linked adrenoleukodystrophy.