These aggregates stem from reversible dynamic LLPS transitioning into irreversible clusters, such as α‐synuclein in Parkinson's disease (PD), tau in Alzheimer's disease (AD), fused in sarcoma (FUS), and TAR DNA‐binding protein 43 (TDP‐43) in amyotrophic lateral sclerosis (ALS) [128]. Here, TARDBP is linked to early-onset autosomal dominant Alzheimer disease.