In this study, we identified several biological variables, including serum concentrations of both pro- and anti-inflammatory cytokines (IL-1β and IL-10), biochemical parameters (albumin, globulins, ALT, ALP, and creatinine), hematological variables (WBCs, neutrophils) and BCS, that predicted, either independently or in combination, five cognitive domains (sleep–wake cycle, social interactions, anxiety, activity, and house-soiling) assessed using the feline cognitive disfunction rating chart (FCDRC) in a population of cats aged 7 years and older. The gene discussed is IL10; the disease is Anxiety.