In glioma, interleukins, EGF, fibronectin, and HSPG are frequently overexpressed (Zhao et al., 2017) and positively regulate the cell adhesion, proliferation, growth, metastasis, and wound healing processes, thereby contributing to glioma progression and TME remodeling (Zhao et al., 2017; Quail and Joyce, 2017). This evidence concerns the gene EGF and central nervous system cancer.