This SHH/Gli signaling pathway is significant for the self-renewal of brain tumor stem cells (BTSC) and is essential for sustained tumor growth and survival of gliomas (Charles and Holland, 2010; Becher et al., 2008; Clement et al., 2007; Stecca and Ruiz i Altaba, 2005). The gene discussed is GLI1; the disease is central nervous system cancer.