MIRAGE is an acronym for a multi‐organ syndrome of myelodysplasia, infection, restriction of growth, adrenal hyperplasia, genital phenotypes, and enteropathy caused by gain‐of‐function (GOF) mutations in SAMD9 which most frequently results in adrenal insufficiency and inherited bone marrow failure (IBMF). The gene discussed is SAMD9; the disease is MIRAGE syndrome.