In patients with BLCA and bone metastases, the AS factor JUP (junction plakoglobin) was identified as a regulator of the AP of SMOX (spermine oxidase) and the exon-skipping event of ITGB4 (integrin subunit beta 4), which influences BLCA metastasis [254]. The gene discussed is JUP; the disease is bladder transitional cell carcinoma.