PTBP1 and bone neoplasm: Our review systematically summarizes the latest advances in the field, covering the fundamental processes and regulatory factors of human pre-mRNA splicing; the roles of key AS regulators in bone biology and bone tumors; the functions of representative AS events in bone remodeling and tumor progression; the molecular mechanisms by which RNA-binding proteins (RBPs) regulate AS in bone biology and bone tumors; and the potential translational value of AS targets in clinical applications.