PKM and neoplasm: 1. Accelerated proliferation: Generation of pro-proliferative or anti-apoptotic variants (e.g., PKM2 and BCL-XL).2. Invasion and metastasis: Variants of adhesion, cytoskeleton, and EMT-related genes are affected, enhancing cell migratory capacity.3. Angiogenesis: Selection of variants that favor tumor survival (e.g., increased VEGF165 variant).4. Therapy resistance: Production of drug-resistant variants (e.g., AR-V7 against anti-androgen therapy).