Furthermore, neuroinflammation is another key feature of neurodegenerative diseases, including Alzheimer’s disease, and may precede clinical symptoms by years or even decades.2,4,18,19 Sustained immune responses in the brain, primarily mediated by activated microglia and astrocytes, are closely linked to neurodegeneration.2,18,19 These glial cells have been shown to modulate the clearance and production of Aβ42 and contribute to the development and propagation of tau pathology.20-22. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.