characterize the associations between objective nocturnal polysomnography (NPSG) macro and microstructure derived sleep parameters and fluid biomarkers of astrocytic activation (CSF GFAP, YKL-40 and plasma GFAP), neuroaxonal injury (plasma NfL) and Alzheimer’s disease-related proteins (CSF Aβ40, Aβ42, pTau181 and tTau) in cognitively unimpaired adults;. Here, GFAP is linked to early-onset autosomal dominant Alzheimer disease.