In our sample, lighter sleep predicted higher concentrations of CSF Aβ40, pTau181 and tTau, supporting prior evidence that experimental sleep deprivation elevates amyloid-β and tau in CU individuals.5,6,71 Altogether, these results suggest that both astrocytic and Alzheimer’s disease-related biomarkers are associated with subtle variations in sleep physiology. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.