MAPT and Alzheimer disease: Ageing is associated with chronic low-grade inflammation—often referred to as ‘inflammaging’—which has been linked to poorer sleep quality, including more frequent and prolonged nighttime awakenings.46-48 Age-related glial activation has also been associated with sleep microstructure disruption, tau phosphorylation, synaptic loss and memory impairment, even in the absence of β-amyloid positivity.49 These converging associations point towards a complex interplay between sleep, neuroinflammation, and Alzheimer’s disease-related processes.