MARCHF6 and Progressive myoclonic epilepsy: We have previously noted that historically FAME families were likely conflated with PMEs12 and hypothesized that PME and FAME lie on a phenotypic spectrum, and FAME-like expansions may cause milder, later-onset PME.13 We generated short-read whole genome sequencing (WGS) data and searched for known and novel REs, then performed molecular validation and long-read sequencing to characterize novel, complex configurations of the FAME3 RE identified in two families.