SAMD12 and benign adult familial myoclonic epilepsy: FAME is caused by the insertion of an intronic pathogenic TTTCA expansion in at least seven different genes, causing FAME1-4 and FAME6-8.5-9 The FAME expansions all have similar, complex repeat structures containing expansions of multiple repeat motifs, a characteristic also shared by other pentanucleotide repeat disorders.11 Most FAMEs are observed with adjacent TTTCA and TTTTA expansions;5-9 however, for FAME6, FAME7, and in a small number of FAME1 families, the pathogenic TTTCA expansion is surrounded by TTTTA repeats.5