The FAME3 locus is not targeted by WES but off-target reads may be informative, as this strategy was previously shown to be successful for some individuals with the non-coding RE that causes cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS).24 Ten individuals identified with three or more read pairs containing (nearly) pure TTGTA repeat sequences were investigated using long-range PCR and targeted nanopore sequencing. Here, MARCHF6 is linked to neuropathy.