LCN2 and necrotizing enterocolitis: A meta-analysis by Yanqiu et al. (97) indicated that FC has high value for the early diagnosis of NEC (sensitivity = 0.86, specificity = 0.80, AUC = 0.913).A multicenter prospective study showed that the combined detection of FC and Lipocalin-2 (LCN2) can improve the sensitivity of early prediction for NEC; notably, changes in these indicators can be observed as early as 10 days before symptom onset, providing advance warning for the early identification of NEC (98, 99).