GM2A and necrotizing enterocolitis: Through gene resequencing, a study by Zhou et al. (106) found that the rs2075783 polymorphism in exon 1 of the GM2A gene and the rs1048719 polymorphism in the intronic region of this gene are associated with the development of NEC, while the rs11465996 polymorphism in the promoter region of the MD-2 gene is associated with the severity of NEC.