The following search terms and their variants were employed using Boolean operators: (“Apert syndrome” OR “Acrocephalosyndactyly”) AND (“FGFR2” OR “Fibroblast Growth Factor Receptor 2” OR “S252W” OR “P253R”) AND (“prenatal diagnosis” OR “prenatal ultrasound” OR “prenatal imaging” OR “fetal MRI” OR “magnetic resonance imaging”) AND (“craniosynostosis” OR “syndactyly” OR “mitten hand” OR “sock foot”) AND (“multidisciplinary management” OR “surgical intervention” OR “airway management” OR “EXIT” OR “neurodevelopment”). The gene discussed is FGFR2; the disease is Apert syndrome.