PAL (plasma-activated Ringer’s) induces ferroptosis in MM cells, with NO/iNOS playing a central role (lysosomal NO/peroxynitrite contributes to lipid peroxidation and ferroptosis); inhibition of NO or iNOS reduced PAL-induced ferroptosis. Context is PAL exposure—NO here contributes to ferroptosis. This evidence concerns the gene NOS2 and Miyoshi myopathy.