KL and neoplasm: This strategy’s main goal is to upset the lactate metabolic homeostasis inside tumor cells, which is accomplished mainly by three main methods: first, blocking the production of lactate (for example, by targeting lactate dehydrogenase, or LDH) and its transport (for example, by targeting monocarboxylate transporters, or MCTs); Second, “writers” (like lactosyltransferases) and “erasers” (such lactate deacetylases) dynamically regulate Kla itself (85)(Figure 5).