The second most-cited article, Behavior and Global Expression Profiles Reveal Mechanistic Differences in Neuropathic Pain Types (19), published in Cell Reports by Boston Children’s Hospital in 2018, highlighted mechanism-based interventions for neuropathic pain following peripheral nerve injury, including targeting TrpV1-positive nociceptors and immune cell modulation. The gene discussed is TRPV1; the disease is peripheral nerve injury.