A subset of 9 protein-coding genes, POLR2F, SLC16A8, CPSF3, PXDN, TGFA, PLA2G6, MAFF, TMEM184B, and CSNK1E, met statistical criteria in both analysis models, indicating that they are reliable and high-confidence candidate genes for glioma susceptibility. The gene discussed is CPSF3; the disease is central nervous system cancer.