Moreover, oncogenic signaling through EGFR and PI3K/AKT converges with metabolic rewiring and post-translational modifications, including PKM2 O-GlcNAcylation and PTEN succination, while spatially resolved profiling has emphasized tumor heterogeneity and the roles of neuronal interactions and lipid-laden macrophages in immune evasion (37). Here, AKT1 is linked to neoplasm.