VEGFA and neoplasm: Second, chronic inflammation alters the tissue microenvironment by upregulating angiogenic factors, such as vascular endothelial growth factor, which promotes angiogenesis and increases the recruitment of immunosuppressive cells (e.g., regulatory T [Treg] cells, myeloid‐derived suppressor cells [MDSCs], and tumor‐associated macrophages [TAMs]), thereby supporting tumor survival and invasion [116].