Proposed explanations include low‐grade inflammation with signal transducer and activator of transcription 3‐mediated programmed death‐1 upregulation, insulin/insulin‐like growth factor‐1 signaling, adipokine imbalance, stromal fibrosis and hypoxia, and metabolic reprogramming that may alter T‐cell function and tumor immunogenicity. Here, STAT3 is linked to neoplasm.