Obesity‐related type I inflammatory cytokines (e.g., IFN‐γ, TNF, leptin, insulin, and palmitic acid) promote TAM PD‐1 expression through mechanistic target of rapamycin complex 1 (mTORC1) and glycolysis‐dependent mechanisms. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.