IL6 and obesity due to melanocortin 4 receptor deficiency: Compared with the obese group, the fat‐associated macrophages in the weight loss group shift toward a less inflammatory subtype, and the levels of proinflammatory chemokines (C‐X‐C motif chemokine ligand 2 (CXCL2), CCL2, and IL‐6) and putative stress signals (transforming growth factor beta 1, amphiregulin, nicotinamide phosphoribosyltransferase, and thrombospondin‐1) in the microenvironment are significantly reduced, indicating that weight loss can reverse the inflammation and stress caused by obesity [114].