A total of 10/11 (90.9%) cases in the fetuses with microcephaly had CPA/HA ratio > 95th centile, 6/11 (54.5%) cases had CPL/OFD ratio > 95th centile, and 7/11 (63.6%) cases had HC/AC ratio < 5th centile. The gene discussed is CPA1; the disease is microcephaly.