CRP and nicotine dependence: Additionally, higher ELS was associated with higher IL-1ra (r = 0.19), nicotine dependence was positively associated with higher CRP (r = 0.30) and IL-6 (r = 0.36), and physical activity (r = −0.18) and nutrition (r = −0.20) were negatively correlated with IL-6 (all rs p < 0.05).