Quercetin can reduce the expression of inflammatory cytokines and BBB permeability marker genes (Mmp9, Vegf, Ang-2, and Et-1), increase the expression of angiogenesis genes (Sema4D and PlexinB1), reduce parasite-induced tight junction disruption, and inhibit the activation of the parasite-induced PI3K/AKT/extracellular signal-regulated kinase (ERK) signaling pathway, thus exerting a therapeutic effect on meningitis (Sun et al., 2024). The gene discussed is AKT1; the disease is meningitis.