Additionally, wogonin can reduce the expression of pro-inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin (IL)-1β] and pro-oxidative enzymes after intracerebral hemorrhage, significantly alleviating inflammatory and oxidative stress responses in the mouse model of intracerebral hemorrhage (Zhuang et al., 2021). The gene discussed is IL1B; the disease is intracerebral hemorrhage.