AKT1 and brain infarction: It can activate the PI3K/AKT signaling pathway, promote the expression of p-AKT, increase the p-AKT/AKT ratio, up-regulate the expression of the anti-apoptotic protein B-cell lymphoma-2, down-regulate the expression of the pro-apoptotic protein Bax protein, inhibit nerve cell apoptosis, reduce cerebral infarction volume and brain water content, thereby treating cerebral infarction (Yang et al., 2020).