In both the training and validation sets, the AUC values for CYP1B1 and TNFAIP6 were all greater than 0.7, indicating that CYP1B1 and TNFAIP6 had a high diagnostic value for IDD (Figure S4, Panels A–D in the Online Supplementary Document). The gene discussed is TNFAIP6; the disease is intervertebral disk degenerative disorder.