TNFAIP6 and intervertebral disk degenerative disorder: Disruption of FA signalling mediated by TNFAIP6 (Figure S5, Panel C in the Online Supplementary Document) can release additional ECM fragments, such as fibronectin, triggering a vicious cycle of ‘ECM degradation → autoimmune response → inflammation amplification.’ Collectively, CYP1B1 and TNFAIP6 appear to drive the ‘inflammation-immune imbalance-ECM destruction’ axis in IDD by modulating γδ T cells, macrophage polarisation, and memory B cell activation.