Pathophysiological connections were robustly characterized: Hsieh et al. [64] linked impaired Miro degradation to defective mitophagy in familial and sporadic PD using iPSC-derived neurons, while Grassi et al. [65] identified neurotoxic Pα-syn* aggregates inducing mitochondrial damage and fragmentation that trigger Parkin-dependent mitophagy. Here, PRKN is linked to Parkinson disease.