Treatment with BMN673 combined with CQ or BAF led to a further increase in the accumulation of LC3II and SQSTM1/p62 in both SK-CO-1 and shATM-RKO cells compared with single treatments alone, suggesting that BMN673 could promote complete autophagic flux in ATM-deficient CRC cells (Fig. 2g, h and Fig. S2c). This evidence concerns the gene ATM and colorectal carcinoma.