The link of NLRP6 with both neuroinflammation and inflammatory bowel diseases such as Crohn’s disease opens fascinating new research questions in the light of NLRP6 being a cellular homeostasis guard and its potential contribution to these malignancies (Angosto-Bazarra et al, 2022; Bracey et al, 2021). The gene discussed is NLRP6; the disease is Crohn disease.