NLRP6 and colitis: The initially reported putative role of NLRP6 in modulating microbiome composition, also in the context of colitis or tumorigenesis (e.g., Levy et al, 2015), was contested in subsequent studies (e.g., Mamantopoulos et al, 2017), illustrating the challenges of identifying bona fide roles of NLRP6 in a system as complex as the intestine.