At PFDR < 0.05, eight CSF proteins (APOE, PILRA-M14, PILRA-deltaTM, FcRIIIa, BGAT, PLA2R, TIMD3, TPSNR) and four plasma proteins (EPHB4, HTRA1, PILRA-M14, PILRA-deltaTM) were associated with dementia, while one CSF protein (BGAT) and one plasma protein (FBLN3) were associated with any stroke and ischemic stroke (Supplementary Tables 20–22). This evidence concerns the gene EFEMP1 and stroke disorder.