KRAS and colorectal cancer: To investigate the effects of different KRAS G12 mutants, we first characterised the SW48 isogenic colorectal cancer cell line harbouring heterozygous mutations in KRAS at codon 12 (SW48+/+, SW48+/G12A, SW48+/G12C, SW48+/G12D, SW48+/G12V, hereafter also referred to as WT, G12A/C/D/V).