KRAS and colorectal adenocarcinoma: We selected the G12D and G12V mutations because of their high frequency across all KRAS-driven cancers (including colorectal cancer), G12C for its high prevalence only in lung adenocarcinoma, and G12A because it is infrequently observed in colorectal adenocarcinoma yet biochemically indistinguishable from G12V (Hunter et al, 2015a).