Global and conditional BACE1 knockout (BACE1-KO) mice exhibit several neuropsychiatrically relevant phenotypes including increased locomotion and ataxia, spontaneous seizures, schizophrenia-related features, decreased thermal pain thresholds, and hearing loss, accompanied at the network and cellular level by neuronal hyperexcitability, aberrant synaptic transmission, axon guidance defects, and impaired axonal myelination (Kandalepas and Vassar, 2014; Weber et al, 2017). Here, BACE1 is linked to schizophrenia.