ACE and hypertensive disorder: Comorbidities (e.g., diabetes mellitus, coronary artery disease, hypertension) and medications (e.g., anticoagulants, beta-blockers, ACE inhibitors) were evenly distributed between groups, with no statistically significant differences (p > 0.05 for all comparisons, Supplementary File S1, Table S1.2-S1.3).