We detected a significant PheWAS association (p = 7.4e-7) between an rG4-breaking variant in the \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${5}^{{\prime} }$$\end{document}5′ UTR of EPN3 and breast cancer (Fig. 4b). Here, EPN3 is linked to breast cancer.