KDM5A and lentivirus infection: For the KDM5A lentivirus infection, the lentiviral vectors were transfected into 293 T cells with the sh-NC and sh-KDM5A packaging plasmid mix in serum-free Opti-MEM using the lipofectamine 3000 reagent with multiplicity of infection (MOI) of 20 and with or without 5 μg/ml polybrene.