Human donor eyes with diabetic retinopathy (DR) exhibited similar disorganization and reduction in PSD95 and RIBEYE in the macular outer plexiform layer (OPL) when compared to healthy controls (Fig 3G and H), and no substantial changes were observed in other synapse proteins, such as EAAT5 (Fig S4D). This evidence concerns the gene DLG4 and diabetic retinopathy.