PNPLA2 and fatty liver disease: ,24,25 Although whole body ATGL-deficient mice have significant cardiomyopathy, mice with adipocyte-specific deletion of ATGL have preserved heart function and exhibit reduced cardiac injury and fibrosis compared with WT mice in multiple models of cardiac injury.24, 25, 26 Interestingly, Mathur et al17 found that mice deficient in adipocyte lipolysis were protected from ethanol-induced hepatic steatosis and oxidative stress, but not liver inflammation.17