Second, to determine if the social adversity effect is maintained using a different definition of the dementia genetic risk profile, individuals were categorized into three genetic risk profiles based on quartiles of AD dementia polygenic risk scores that do not include APOE alleles: low (< 25th quartile score), intermediate (25th - 75th quartile score), and high (> 75th quartile score) polygenic risk profiles. The gene discussed is APOE; the disease is dementia.