APOE and dementia: In contrast, as social adversity levels increased, dementia risk was greater and similar among APOE allele profiles, compared to people at intermediate genetic risk (ε3ε3) exposed to ≤ 1 unfavorable SDH (≥ 4 unfavorable SDH, APOE-ε2 HR = 3.26, 95%CI = 2.06–5.16; APOE-ε3ε3 HR = 3.12, 95%CI = 2.47–3.95; APOE-ε4 HR = 3.21, 95%CI = 2.34–4.41, Random effect (I2) =0.0%) (Fig 1C, Table 2).