APOE and dementia: In the low social adversity level (≤ 1 unfavorable SDH), people at low (ε2) and high (ε4) genetic risk profiles presented the lowest (APOE-ε2 HR = 0.67, 95%CI = 0.48–0.93) and the highest (APOE-ε4 HR = 1.68, 95%CI = 1.37–2.06) risk of dementia, respectively, compared to people at intermediate genetic risk (ε3ε3) exposed to ≤ 1 unfavorable SDH (Fig 1C, Table 2).