Additionally, ING1b induces BCL-2, a well-known anti-apoptotic protein, which also modulates entry into cellular senescence through the regulation of p16INK4a, p27Kip1, and p21Waf1/Cip1 both dependently and independently of AR via crosstalk with ING2 in various PCa cells [105, 106].Annexin2 (ANXA2), a member of the Annexin A family acts as a tumor suppressor in PCa with higher expression significantly associated with improved overall survival in PCa patients. This evidence concerns the gene AR and posterior cortical atrophy.