Genetic variation in TMEM106B is a risk factor for multiple diseases, including frontotemporal lobar degeneration with TPD-43-immunoreactive pathology (FTLD-TDP), limbic-predominant age-related TDP-43 encephalopathy (LATE), and AD in APOE ε4 negative individuals [18, 22, 58]. The gene discussed is TMEM106B; the disease is Alzheimer disease.