Our results revealed that all these molecular markers, i.e., cleaved caspase-1, cleaved-GSDMD, cleaved-GSDME, cleaved-caspase-3, cleaved-caspase-8, NLRP3, phosphorylation of MLKL, phosphorylation of RIPK3, and RIG-I, were significantly increased following ZIKV infection, suggesting that ZIKV might have caused PANoptosis activation in the placentas (Fig. 1J). Here, CASP3 is linked to Zika virus infectious disease.