APOE and Mental deterioration: Similarly, a study of 300 women (never users mean age 72.5 years, past users mean age 71.9 years, current users mean age 70.6 years) found that while cognitive performance declined over 6 years in all non‐users and current HRT users who were not APOE ε4 carriers, APOE ε4 carriers and HRT users did not show cognitive decline during the study period.231