For the first time, this study demonstrates that increased expression of CXCL12‐CXCR4 and SNAIL, along with high infiltration of M2‐TAMs in a +HPV/XPO5 TME and an activated STAT3/NF‐κB signaling pathway, is significantly associated with higher mortality risk in cervical cancer patients with FOXP3/HLA‐G polymorphisms. This evidence concerns the gene CXCR4 and cervical cancer.