We propose that targeting the CXCL12‐CXCR4 axis, SNAIL, FOXP3, and its rs3761549 variant in an oncogenic HPV/XPO5 TME—characterized by high M2‐TAM infiltration and STAT3/NF‐κB upregulation—may help counteract immunosuppression and metastasis in cervical cancer. Here, CXCR4 is linked to cervical cancer.