Many tumors evade immune surveillance by downregulating MHC class I, impairing antigen processing, resisting apoptosis, and attracting immunosuppressive cells.[4] Within the tumor microenvironment (TME), tumor‐associated 2 macrophages (M2‐TAMs) actively promote tumor growth, vascularization, and stromal modulation through STAT3/NF‐κB pathway interactions.[5, 6, 7]. Here, STAT3 is linked to neoplasm.