There is substantial evidence of complex interactions among stromal cells, such as M2‐TAM, viruses, and tumor cells, mediated by immunosuppressive cytokine loops within the tumor microenvironment (TME).[46] Our findings suggest that the upregulation of STAT3/NF‐κB, along with high M2‐TAM infiltration—potentially influenced by lifestyle and clinical factors such as smoking and age (>45 years)—leads to an immunosuppressive TME. Here, STAT3 is linked to neoplasm.