HCRT and obesity due to melanocortin 4 receptor deficiency: In addition, given the established roles of AdoMet and Orexin-A in neuro-metabolic homeostasis, the observed modulation may also have relevance for conditions such as obesity, insulin resistance, type 2 diabetes, and neurodegenerative diseases characterized by metabolic dysregulation (Liu Y et al., 2024; Wang et al., 2022).