In addition, given the established roles of AdoMet and Orexin-A in neuro-metabolic homeostasis, the observed modulation may also have relevance for conditions such as obesity, insulin resistance, type 2 diabetes, and neurodegenerative diseases characterized by metabolic dysregulation (Liu Y et al., 2024; Wang et al., 2022). The gene discussed is HCRT; the disease is type 2 diabetes mellitus.