This association is reinforced by the meta-analysis by Zhou et al., which integrated data from 28 studies and identified interstitial lung abnormalities, pulmonary fibrosis, and ILD as leading predictors of CIP, alongside factors such as squamous cell carcinoma histology and PD-L1 expression ≥50% (19). The gene discussed is CD274; the disease is hereditary sensory and autonomic neuropathy.