Hormonal therapy options include oral contraceptives and GnRH agonists; oral contraceptives are generally preferred, as GnRH agonists induce hypoestrogenic effects, which may lead to treatment discontinuation and higher chances of Catamenial pneumothorax recurrence [9]. Recent studies also support the use of progestin-only agents, such as dienogest or norethindrone acetate, which effectively suppress ovulation while minimizing hypoestrogenic symptoms [13,14]. Here, GNRH1 is linked to pneumothorax.