("Diabetic Ketoacidosis"[Mesh] OR "DKA" OR "diabetic ketoacidosis" OR "ketoacidosis, diabetic") AND ("Hypoglycemia"[Mesh] OR "hypoglycemia" OR "low blood glucose") AND ("Insulin"[Mesh] OR "insulin therapy" OR "insulin regimen" OR "intravenous insulin") AND ("Fluid Therapy"[Mesh] OR "intravenous fluids" OR "fluid replacement" OR "rehydration") AND ("Randomized Controlled Trial"[Publication Type] OR "Cohort Studies"[Mesh] OR "Clinical Study"). This evidence concerns the gene INS and type 2 diabetes mellitus.