Nine high-confidence genes were identified as potential regulators of RNA abnormalities (Fig. S3B), with elevated expression of secretory 61 beta (SEC61B), small nuclear ribonucleoprotein polypeptide E (SNRPE), and transformer 2 beta TRA2B correlating with poorer prognosis in patients with non-small cell lung cancer (Fig. S3C). The gene discussed is SNRPE; the disease is non-small cell lung carcinoma.