SOX2 and cancer: Previous research suggests that the significant amplification of fibroblast growth factor receptor (FGFR) in squamous carcinoma, and the regulation of sex determining region Y-box 2 (SOX2)-induced differentiation by cancer-associated fibroblasts in LUSC,4 indicates that IGFBP2+ fibroblasts have the potential to regulate adeno-squamous transdifferentiation.5